1. A newly Married woman going for a weekend of drinking and debauchery with a single friend in New Orleans.
This x 1000
OP, Thursday to Monday in New Orleans. Let's see. They certainly will go to Pat O'Briens and try the Hurricanes. At least one, maybe a second. The drinks are fruity. 30-60 minutes later she will barely be able to stand. They will feel great. They may or may not get hit on there if they are receptive, but they will feel great and then go to any other bar near there and certainly get hit on. Repeatedly. Guys will by them drinks. They will love that and it won't cost them a cent.
Years ago. my buddy and I started at Pat O's. Two hurricanes later, maybe three, I could barely talk. We went to an storefront Chinese restaurant. While I was ordering this drunk blonde came in. We started a chat. She starting eating my food. WTF? No problem there. She invited us to a party. Told us where to go when her friends came to find her. The fish that got away.
We spent a hour trying to find her, gave up and went to another bar. While in line waiting for table we met these two dunk college girls. Starting chatting. Shared a table. We paired up. 10 minutes later, getting physical. We showed them the town. I went home with my pair off. Where did she start her afternoon? Pat O's with hurricanes.
I ended up marrying her. So I have New Orleans and Pat O's to thank/blame for my marriage. I've been to NO dozens of times. Gotten drunk most of the time and I am not even a tourist.
TLDR: Your wife will get very drunk in NO and get hit on. Repeatedly. Whether she can resist cheating is your call.
But all that is incidental to what the others said. This is a power struggle.